Interdisciplinary graduate program in

Molecular & Cellular Biology
Discovery is the name of the game.

Student Publications

Below is a list of publications and abstracts published by current students in the Molecular & Cellular Biology Program. The names of the students are in bold


Shvetsov, A., Galkin, V.E., Orlova, A., Phillips, M., Bergeron , S.E., Rubenstein, P.A., Egelman, E.H., and Reisler, E. Actin Hydrophobic Loop (262-274) and Filament Nucleation and Elongation. J. of Molecular Biology. 2007, in press.

Cheng , B. and Price, D.H. Properties of RNA Polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. J Biol. Chem. 282(30):21901-12, 2007.

Abstracts

Cheng , B. and Price, D.H. Properties of RNA Polymerase II elongation complexes before and after the P-TEFb-mediated transition into productive elongation. Cold Spring Harbor Meeting on Mechanisms of Eukaryotic Transcription, NY, Aug. 29th-Sep. 2nd, 2007.

Cheng , B. and Price, D.H. Dissection of the functional mechanisms of P-TEFb in RNA Polymerase II elongation control. 13th Biennial Meeting on Post-Initiation Activities of RNA Polymerases, VA, Nov. 2nd-5th, 2006.

Cheng , B. and Price, D.H. Analysis of RNA Polymerase II elongation control using a defined in vitro system. Midwest Meeting on Chromatin, Transcription and Nuclear Dynamics, IA, Jul. 14th-16th, 2006.

Cheng , B., Li, Qintong, Price, J.P. and Price, D.H. Analysis of control of P-TEFb function using a defined in vitro transcription system. Keystone Symposia Conference on Regulation of Eukaryotic Transcription: From Chromatin to mRNA, NM, Apr. 21st-26th, 2006.

Howell , C. A., Prakash, S., and Washington, M. T. Pre-steady state kinetic studies of protein-template directed nucleotide incorporation by the yeast Rev1 protein. Biochem. In press.

Howell , C.A., Kondratick, C.M. and Washington, M.T. Substitution of a Residue Contacting the Incoming Nucleotide Increases Fidelity and Decreases Misextension by Yeast DNA Polymerase zeta. DNA Repair. Submitted, 2007.

Yao, C., Luo, J., Hsiao , C.-H. C., Donelson, J.E., and Wilson, M.E. Internal and surface subpopulations of the major surface protease (MSP) of Leishmania chagasi. Mol. Biochem. Parasitol. Feb;139(2):173-83, 2005.

Yao, C., Luo, J., Hsiao , C.-H. C., Donelson, J.E., and Wilson, M.E.. Leishmania chagasi: Tetracycline inducible system driven by T7 RNA polymerase. Exp. Parasitol. Jul;116(3):205-13, 2007.

Hsiao , C.H., Yao, C., Storlie, P., Donelson, J.E. and Wilson, M.E. The major surface protease (MSP or GP63) in the intracellular amastigote stage of Leishmania chagasi. Mol. Biochem. Parasitol. 2007, In Press.

Abstracts

Hsiao , C.-H. C., Yao C., Donelson J.E., and Wilson M.E. The major surface protease (MSP or GP63) on different life stages of Leishmania chagasi. The American Society of Tropical Medicine and Hygiene, Washington, DC, December 11-15, 2005.

Storlie, P. A., Hsiao , C.-H. C., Yao C. Miller M. A., Donelson J. E., and Wilson M. E. Design and characterization of monoclonal antibodies to distinguish between MSP isoforms found on the surface of Leishmania chagasi. The American Society of Tropical Medicine and Hygiene, Atlanta, Georgia, November 12-16, 2006.

Hsiao , C.-H. C., Yao C., Donelson J.E., and Wilson M.E. Characterization of major surface protease (MSP) in axenic cultured amastigotes of Leishmania chagasi. American Society for Biochemistry and Molecular Biology, Washington, DC, April 28- May 2, 2007.

Hsiao , C.-H. C., Yao C., Donelson J.E., and Wilson M.E. The major surface protease (MSP) in the obligate intracellular amastigote form of Leishmania chagasi. Annual Midwestern Conference of Parasitologists, Oshkosh, Wisconsin, June 14- 16, 2007.

Westin, E.R., Chavez, E., Lee, K.M., Gourronc, F.A., Riley, S., Lansdrop, P.M., Goldman, F.D. and Klingelhutz, A.J. Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts. Aging Cell 3:383-94, 2007.

Abstracts

Kimani , P.K., and McGowan, S.E. The role of Platelet-derived Growth Factor A in Pulmonary Myofibroblast Differentiation and Function during Alveolar Development. American Thoracic Society Annual Meeting, San Fransisco, CA, 2007.`

Kimani , P.K., and Phelps, C.J. Dopaminergic neurons that also produce GHRH: Quantification of a subpopulation in the mouse arcuate nucleus using double immunofluorescence. Society for Neuroscience Annual Meeting, New Orleans, LA, 2003.

Krueger , B.J., Jeronimo, C., Roy, B.B., Bouchard, A., Barrandon, C., Byers, S.A., Searcey, C.E., Cooper, J.J., Bensaude, O., Cohen, E.A., Coulombe, B., and Price, D.H. LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated. Nuc. Acids Res., 36:2219-2229, 2008.

Leach , N., Bjerke, S.L., Christensen, D.K., Bouchard, J.M., Mou, F., Park, R., Baines, J., Haraguchi, T., and Roller, R.J. Emerin is hyperphosphorylated and redistributed in herpes simplex virus type 1-infected cells in a manner dependent on both UL34 and US3. J. Virol. 81(19):10792-803, 2007.

Abstracts

Bjerke, S. L., Leach , N., Christensen, D., and Roller, R. International Herpes Workshop: HSV-1 INFECTION ALTERS THE LOCALIZATION MODIFICATION OF LAMIN-ASSOCIATED PROTEINS EMERIN AND LAP2 IN A UL34 AND US3-DEPENDENT MANNER.

Marquez , R.T. and McCaffrey, A.P. Advances in MicroRNAs: Implications for Gene Therapists. Human Gene Therapy, 19:27-37, 2008..

Park , K. and Russo, A.F. Control of the calcitonin gene-related peptide enhancer by upstream stimulatory factor in trigeminal ganglion neurons, J. Biol. Chem., J Biol. Chem., 283(9):5441-51, 2008.

Abstracts

Pinto , B.S., Wilmington, S.R., Hornick, E.E.L., Wallrath, L.L. and Geyer, P.K.Genetic analyses reveal tissue-specific contributions of the Drosophila LEM domain proteins in the nuclear lamina. 47th Annual ASCB Meeting, 2007.

Pinto , B.S., Wilmington, S.R., Wallrath, L.L. and Geyer, P.K. Using Drosophila as a model to understand human laminopathies: A study of dMAN1. 48th Annual Drosophila Conference, 2007.

Pinto , B.S., Wilmington, S.R., Wallrath, L.L. and Geyer, P.K. Using Drosophila as a model to understand human laminopathies: A study of dMAN1. Midwest Drosophila Conference, 2006.

Pinto , B.S., Wilmington, S.R., Schulze, S.R., Wallrath, L.L. and Geyer, P.K. A Study of LEM domain proteins in Drosophila: Characterization of the putative MAN1 homologue. 47th Annual Drosophila Research Conference, 2006.

Pinto , B.S., Wilmington, S.R., Yazgan, O., McDonough, C. W., Nalbant, D., Wallrath, L.L. and Geyer, P.K. A Study of LEM domain proteins in Drosophila: Characterization of the putative MAN1 homologue. ASCB Summer Meeting, Nuclear Architecture and Disease, 2005.

Abstracts

Shah , A.S., Farmen, S.L., Moninger, T.O., Andrews, M.P., Businga, T.R., Searby, C.C., Nishimura, D., Brogden, K.A., Kline, J. N., Sheffield, V.C., and Welsh, M.J. Loss of Bardet-Biedl protein alters the morphology and function of motile cilia in airway epithelia. American Society for Cell Biology Annual Meeting, 2007.

Publications:

Shah , A.S., Farmen, S.L., Moninger, T.O., Businga, T.R., Andrews, M.P., Bugge, K., Searby, C.C., Nishimura, D., Brogden, K.A., Kline, J.N., Sheffield, V.C., and Welsh, M.J. Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia. PNAS, 105:3380-0385, 2008.



Semiglazov, V.F., Ailamazian, E.K., Bailiuk, E.N., Niauri, D.A., Ivanov, V.G., Manikhas, A.G., Kvetnoi, I.M., and Soshnev , A.A. Prophylaxis of breast cancer in patients with reproductive system hyperproliferative disorders. Vopr Onkol. 2006;52(3):247-57. [Article in Russian]

Abstracts

Soshnev , A.A., Li, X.-G., Wehling, M.D., McCluskey, B.J., Parnell, T.J., Kuhn, E.J., and Geyer, P.K. Determining the role of the Su(Hw) 1A2 insulator within the yellow-achaete intergenic region. 2007 Midwest Drosophila Conference.

Butler, D.K., All, O., Goffena, J., Loveless, T., Wilson , T., and Toenjes, K.A., The GRR1 gene of Candida albicans is involved in the negative control of pseudohyphal morphogenesis. Fungal Genet Biol. 43(8):573-82, 2006.

Winborn , B.J., Travis, S.M., Todi, S.V., Miller, V.M., Williams, A.J., Cohen, R.E., Paulson, H.L. The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein edits K63-linked and mixed linkage ubiquitin chains. Manuscript submitted

Todi, S.V., Winborn , B.J., Williams, A.J., Scaglione, K.M., Paulson, H.L. The catalytic activity of the polyglutamine protein ataxin-3 is modulated by its state of ubiquitination. Manuscript in preparation for submission

Todi, S.V., Laco, M.N., Winborn , B.J., Travis, S.M., Wen, H.M., Paulson, H.L. Cellular turnover of the polyglutamine disease protein ataxin-3 is regulated by its catalytic activity. Journal of Biological Chemistry, 282 (40): 29348-58, 2007.

Abstracts:

Winborn , B.J., Travis, S.M., Todi, S.V., Xu, P. Peng, J., Cohen, R.E. and Paulson, H.L. The deubiquitinating enzyme ataxin-3 edits K63-linkages in mixed linkage ubiquitin chains. Platform presentation and poster at American Society of Biochemistry and Molecular Biology Annual Meeting, San Diego, CA, April 5-9 2008

Todi, S.V., Winborn , B.J., Williams, A.J., and Paulson, H.L. Ubiquitination of the polyglutamine disease protein ataxin 3 enhances its activity as a deubiquitinating enzyme. Poster at American Society for Biochemistry and Molecular Biology Annual Meeting, San Diego, CA, April 5-9 2008.

Winborn , B.J., Travis, S.M., Todi, S.V., Xu, P. Peng, J., Cohen, R.E. and Paulson, H.L. The deubiquitinating enzyme ataxin-3 edits K63-linkages in mixed linkage ubiquitin chains. Platform presentation and poster at Graduate Student Symposium at St. Jude Children’s Hospital, Memphis, TN, March 25-29 2008

Winborn , B.J., Travis, S.M., Todi, S.V., Cohen, R.E. and Paulson, H.L. Ubiquitin chain editing by the neurodegenerative disease protein Ataxin-3. Platform presentation at Midwest Stress Response at Northwestern University, Evanston, IL, January 19, 2008

Winborn , B.J., Travis, S.M., Todi, S.V., Cohen, R.E. and Paulson, H.L. Ataxin-3, a polyglutamine disease protein, edits K63-linked and mixed linkage ubiquitin chains. Platform presentation at The Ubiquitin Family meeting at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, April 25-29 2007

Winborn , B.J., Travis, S.M., Todi, S.V. and Paulson, H.L. Ataxin-3, a polyglutamine disease protein, has K63-linked ubiquitin editing activity. Poster at Carver College of Medicine Research Week, April 2007

Travis, S.M., Winborn , B.J., Paulson, H.L. Ataxin-3, a deubiquitinating enzyme with tandem UIMs: interactions with K48- and K63-linked polyUb chains. Poster at Keystone Symposium on Ubiquitin and Signaling, Big Sky, MT, February 2007

Winborn , B.J., Travis, S.M., Todi, S.V. and Paulson, H.L. Ataxin-3, a polyglutamine disease protein, has K63-linked ubiquitin editing activity. Poster at American Society for Cell Biology Annual Meeting, San Diego, CA, December 2006

Todi, S.V., Winborn , B.J., and Paulson, H.L. The ubiquitin chain-type specific protease ataxin-3 auto-regulates its own levels and affects the stability of other proteins in cells. Platform presentation at Society for Neuroscience Annual Meeting, October 2006