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February 11 (Goswami/Quelle),
paper discussion (2 articles)
"Two
Molecularly Distinct G2/M Checkpoints are Induced by Ionizing Irradiation",
Xu et. al., Mol. Cell. Biol. 2002, 22:1049-1059
"Myc
Suppression of the p21Cip1 Cdk Inhibitor Influences the Outcome of the
p53 Response to DNA Damage", Seoane et. al. Nature 2002, 419:729-734
March 6 (Klingelhutz/Knudson) discussion papers
"Transformation
of normal human cells in the absence of telomerase activation", Seger
et. al. Cancer Cell 2002, 2:401-413
"Distinctive
roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway",
Jiang et. al. Science 2003, 299:223-226
PHAP
Supplemental material
Apoptosis
Lecture (pdf file), Mike Knudson, 2-18-03
Apoptosis
Lecture (pdf file), Mike Knudson, 2-20-03
Apoptosis
Lecture (pdf file), Mike Knudson, 2-25-03
Cell Immortalization/Telomerase, Klingelhutz
Lectures (pdf file), 2-27-03 and 3-4-03
March 25 Koland/Lill discussion papers
"Controlled
Dimerization of ErbB Receptors Provides Evidence for Differential Signaling
by Homo- and Heterodimers", Muthuswamy, et. al. Mol. Cell. Biol.
19:6845-6857, 1999.
"Genetically
Encoded Fluorescent Reporters of Protein Tyrosine Kinase Activities in
Living Cells", Ting, et. al. PNAS 98:15003-15008, 2001.
Rory Fisher - April 22
"Heterodimerization
is Required for the Formation of a Functional GABAB Receptor",
White, et. al. Nature 396:679-682, 1998.
"GABAB
Receptors Function as a Heteromeric Assembly of the Subunits GABABR1
and GABABR2", Jones, et. al. Nature 396:674-679.
"GABAB-receptor
Subtypes Assemble into Functional Heteromeric Complexes", Kaupmann,
et. al. Nature 396:683-687.
Future Lectures:
"Structural
Determinants for Regulation of Phosphodiesterase by a G Protein at 2.0
A", Slep et. al. Nature 409:1071-1077.
"Endogenous
RGS Protein Action Modulates m-Opioid Signaling
through Gao", Clark, et. al. J. Biol.
Chem. 278:9418-9425, 2003.
Papers which the class will choose to critique:
"A
Spatial Focusing Model for G Protein Signals", Zhong, et. al. J.
Biol. Chem. 278:7278-7284.
"Spontaneous
Receptor-independent Heterotrimeric G-protein Signalling in an RGS Mutant",
Siekhaus, et. al. Nature Cell Biol. 5:231-235, 2003.
Rory Fisher - April 29 -
Discussion Papers
"Cytoplasmic,
Nuclear, and Golgi Localization of RGS Proteins", Chatterjee, et.
al. J. Biol. Chem. 275:24013-24021, 2000.
"Novel
Alternative Splicing and Nuclear Localization of Human RGS12 Gene Products",
Chatterjee, et. al. J. Biol. Chem. 275:29660-29671, 2000.
"RGS12TS-S
Localizes at Nuclear Matrix-Associated Subnuclear Structures and Represses
Transcription: Structural Requirements for Subnuclear Targeting and Transcriptional
Repression", Chatterjee, et. al. Mol. Cell. Biology 22:4334-4345,
2002.
Diane Slusarski - May 1-6 - lecture
notes (pdf files)
2
slides per page
6
slides per page
Diane
Slusarski - May 6th - Two versions of Lecture Handouts
Wnt
Lecture 2 slides per page
Wnt
Lecture 6 slides per page
Diane Slusarski -May 8 - discussion paper
"The
DIX Domain Targets Dishevelled to Actin Stress Fibres and Vesicular Membranes",
Capelluto, et. al. Nature 419:726-729.
ANNOUNCEMENT: Note room/time change:
Exam IV
May 15, 2:15-4:15 PM
1-107 BSB
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